Chiral, sequence-definable foldamer-derived macrocycles-Reference-Cited by-同舟云学术

Chiral, sequence-definable foldamer-derived macrocycles

Published:2021 Issue:47 Volume:12 Page:15632-15636
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Warnock Toyah M. C.¹^ORCID,Rajkumar Sundaram²^ORCID,Fitzpatrick Matthew P.¹^ORCID,Serpell Christopher J.³^ORCID,Dingwall Paul¹^ORCID,Knipe Peter C.¹^ORCID

Affiliation:

1. School of Chemistry and Chemical Engineering, Queen's University Belfast, David Keir Building, Belfast, BT9 5AG, UK

2. Almac Group Ltd., 20 Seagoe Industrial Estate, Craigavon, BT63 5QD, UK

3. School of Physical Sciences, University of Kent, Ingram Building, Canterbury, Kent, CT2 7NH, UK

Abstract

Dipole-controlled pre-organization enables the cyclization of sequence-defined foldamers into macrocycles. The structure and properties of trimeric and tetrameric macrocycles are explored, and their ability to bind cationic guests is demonstrated.

Funder

Queen's University Belfast

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC05021D

Reference50 articles.

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2. D. J.Newman and G. M.Cragg , in Macrocycles in Drug Discovery , ed. J. Levin , The Royal Society of Chemistry , 2015 , pp. 1–36