Integrated metabolic profiles and microbial communities to reveal the beneficial effect of red pitaya on early constipation

Author:

Zhao Pengfei1,Meng Xiran2,Sun Mo3,Qin Bingqing2,Kong Shuaiwen2,Xie Lixia2ORCID,Zhang Wei4,Ding Xudong2,Zhang Chenning2ORCID

Affiliation:

1. Department of Clinical Pharmacy, Weifang People's Hospital, Weifang, 261000, China

2. Department of Rehabilitation Medicine & Department of Pharmacy, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang 441000, China

3. School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA

4. School of Natural Sciences, Faculty of Science and Engineering, Macquarie University, NSW 2109, Australia

Abstract

Red pitaya ameliorates loperamide hydrochloride-induced early constipation in mice through modulating gut microbiota and metabolites related to tryptophan metabolism and primary bile acid biosynthesis in feces and serum.

Funder

Natural Science Foundation of Hubei Province

Chinese Medical Association

Publisher

Royal Society of Chemistry (RSC)

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