Nonequilibrium switching of segmental states can influence compaction of chromatin-Reference-Cited by-同舟云学术

Nonequilibrium switching of segmental states can influence compaction of chromatin

Published:2024 Issue:23 Volume:20 Page:4621-4632
ISSN:1744-683X
Container-title:Soft Matter
language:en
Short-container-title:Soft Matter

Author:

Sahoo Soudamini¹²^ORCID,Kadam Sangram³^ORCID,Padinhateeri Ranjith³^ORCID,Kumar P. B. Sunil¹⁴⁵^ORCID

Affiliation:

1. Department of Physics, Indian Institute of Technology Palakkad, Palakkad, 678623, India

2. Department of Physics and Astronomy, National Institute of Technology Rourkela, Rourkela, 769008, India

3. Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India

4. Department of Physics, Indian Institute of Technology Madras, Chennai, 600036, India

5. Center for Soft and Biological Matter, Indian Institute of Technology Madras, Chennai, 600036, India

Abstract

Simulation of a chromatin model with dynamic switching of chromatin regions between different chemical and physical states demonstrate its role in determining its 3D structure. This can drive gene expression differences among different cell types.

Funder

Department of Science and Technology, Ministry of Science and Technology, India

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SM/D4SM00274A

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