Selective reduction of carboxylic esters enabled by a coaxial double-tube continuous-flow reactor with on-the-fly H<sub>2</sub> degassing-Reference-Cited by-同舟云学术

Selective reduction of carboxylic esters enabled by a coaxial double-tube continuous-flow reactor with on-the-fly H₂ degassing

Published:2023 Issue:6 Volume:8 Page:1414-1426
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Wu Jiale¹²,Zheng Xianjing¹²,Wan Li¹²,Tao Yuan¹²,Cheng Dang¹²^ORCID,Chen Fener¹²^ORCID

Affiliation:

1. Engineering Center for Catalysis and Synthesis of Chiral Molecules, Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China

2. Shanghai Engineering & Technology Research Center for Industrial Asymmetric Catalysis of Chiral Drugs, 220 Handan Road, Shanghai 200433, China

Abstract

Herein, a coaxial double-tube continuous-flow reactor is developed, which allows on-the-fly removal of the generated hydrogen gas from the reaction solution. This enables selective borohydride reduction of carboxylic esters to primary alcohols.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RE/D3RE00078H

Reference49 articles.

1. On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system

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4. Multistep continuous-flow synthesis of (R)- and (S)-rolipram using heterogeneous catalysts

5. Seven‐Step Continuous Flow Synthesis of Linezolid Without Intermediate Purification