Nebulizing novel multifunctional nanovesicles: the impact of macrophage-targeted-pH-sensitive archaeosomes on a pulmonary surfactant

Author:

Altube Maria Julia12345ORCID,Cutro Andrea6785,Bakas Laura910115,Morilla Maria Jose12345,Disalvo Edgardo Anibal6785,Romero Eder Lilia12345ORCID

Affiliation:

1. Nanomedicine Research Program-2

2. Science and Technology Department

3. National University of Quilmes

4. Bernal

5. Argentina

6. Laboratory of Biointerphases and Biomimetic Systems

7. (CITSE) National University of Santiago del Estero and CONICET

8. Santiago del Estero

9. Vegetal Proteins Research Laboratory (LIPROVE)

10. Exact Sciences Faculty

11. National University of La Plata

Abstract

Novel nebulized pH-sensitive nanovesicles remain structurally stable after crossing the pulmonary surfactant monolayer and could release a cytoplasmic fluorophore marker into the underlying macrophages.

Funder

Consejo Nacional de Investigaciones Científicas y Técnicas

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Reference69 articles.

1. Liposome Delivery Systems for Inhalation: A Critical Review Highlighting Formulation Issues and Anticancer Applications

2. Lipid-based carriers for pulmonary products: Preclinical development and case studies in humans

3. Disposition and safety of inhaled biodegradable nanomedicines: Opportunities and challenges

4. Delivery strategies for sustained drug release in the lungs

5. D. Cipolla , T.Redelmeier, S.Eastman, P.Bruinenberg and I.Gonda, Nanovesicles, niosomes and proniosomes—a critical update of their (commercial) development as inhaled products, Respiratory drug delivery Europe, 2011, pp. 41–54

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