Automated solid phase assisted synthesis of a heparan sulfate disaccharide library

Author:

Ramadan Sherif12ORCID,Su Guowei3,Baryal Kedar1,Hsieh-Wilson Linda C.4,Liu Jian5,Huang Xuefei167ORCID

Affiliation:

1. Department of Chemistry, Michigan State University, 578 S. Shaw Lane, East Lansing, Michigan 48824, USA

2. Chemistry Department, Faculty of Science, Benha University, Benha, Qaliobiya 13518, Egypt

3. Glycan Therapeutics, 617 Hutton Street, Raleigh, North Carolina 27606, USA

4. Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA

5. Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, USA

6. Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, Michigan 48824, USA

7. Department of Biomedical Engineering, Michigan State University, East Lansing, Michigan 48824, USA

Abstract

An automated machine-aided solid phase synthesis of heparan sulfate (HS) has been established for the first time. With the significantly reduced number of synthetic and purification steps, 16 HS disaccharides have been readily assembled.

Funder

National Institute of General Medical Sciences

Michigan State University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

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