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Design and evaluation of novel thrombin-based GLP-1 analogs with peptidic albumin binding domain for the controlled release of GLP-1

  • Published:2020 Issue:8 Volume:10 Page:4725-4732
  • ISSN:2046-2069
  • Container-title:RSC Advances
  • language:en
  • Short-container-title:RSC Adv.

Author:

Niu Xianli12345,Nong Shirong12345,Zhang Xiaomin67859,Li Xiangyang67859,Wang Cheng67859,Li Wei12345ORCID,Zhou Tianhong12345

Affiliation:

1. Key Laboratory of Genetic Engineering and Medicine

2. Key Laboratory of Viral Biology

3. Jinan University

4. Guangzhou

5. P. R. China

6. Department of Biochemistry and Molecular Biology

7. Zunyi Medical University

8. Zhuhai

9. Fifth Affiliated Hospital of Zunyi Medical University

Abstract

Currently, the curative effects of polypeptide drugs are often restricted due to the short in vivo duration of action.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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