Hydroxyapatite nanoparticle-modified porous bone grafts with improved cell attachment

Author:

Dhavalikar Prachi1,Jenkins Dana1,Rosen Natalie2,Kannapiran Aparajith1,Salhadar Karim1,Shachaf Orren1ORCID,Silverstein Michael2ORCID,Cosgriff-Hernández Elizabeth1ORCID

Affiliation:

1. Department of Biomedical Engineering, University of Texas at Austin, 107 W. Dean Keeton, BME Building, Room 3.503D, Austin, Texas, 78712, USA

2. Department of Materials Science and Engineering, Technion–Israel Institute of Technology, Haifa 32000, Israel

Abstract

Hydroxyapatite nanoparticles and surfactant concentration in polyMIPE scaffolds affect microarchitecture and cell behavior. Co-stabilized polyMIPEs balance these interactions to achieve properties suitable for bone grafting applications.

Funder

United States-Israel Binational Science Foundation

National Institutes of Health

National Science Foundation

Division of Materials Research

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Reference92 articles.

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2. A. S.Greenwald , S. D.Boden , R. L.Barrack , M. P.Bostrom , V. M.Goldberg , M. J.Yaszemski and C. S.Heim , in The evolving role of bone-graft substitutes, American Academy of Orthopedic Surgeons, 77th Anual Meeting [Internet], 2010

3. Engineering of bone using bone marrow stromal cells and a silicon-stabilized tricalcium phosphate bioceramic: Evidence for a coupling between bone formation and scaffold resorption

4. R. S.Moglia , Biomedical Applications of Emulsion Templated Scaffolds , 2014

5. PolyHIPEs: Recent advances in emulsion-templated porous polymers

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