Synthesis and evaluation of the anticancer activity of [Pt(diimine)(N,N-dibutyl-N′-acylthiourea)]+ complexes-Reference-Cited by-同舟云学术

Synthesis and evaluation of the anticancer activity of [Pt(diimine)(N,N-dibutyl-N′-acylthiourea)]+ complexes

Published:2021 Issue:34 Volume:50 Page:11742-11762
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Peega Tebogo¹^ORCID,Magwaza Rachael N.¹,Harmse Leonie²^ORCID,Kotzé Izak A.¹^ORCID

Affiliation:

1. Molecular Science Institute, School of Chemistry, University of the Witwatersrand, Johannesburg, South Africa

2. Division of Pharmacology, Department of Pharmacy and Pharmacology, Faculty of Health Sciences, School of Therapeutic Sciences, University of the Witwatersrand, Johannesburg, South Africa

Abstract

A series of platinum(ii) diimine acylthiourea complexes are reported with potent in vitro activity against two lung cancer cell lines (A549 and H1975) and a colorectal cancer cell line (HT-29) by inducing cell death by both apoptosis and paraptosis.

Funder

National Research Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/DT/D1DT01385H

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