Design, synthesis and in vitro splicing inhibition of desmethyl and carba-derivatives of herboxidiene-Reference-Cited by-同舟云学术

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Design, synthesis and in vitro splicing inhibition of desmethyl and carba-derivatives of herboxidiene

Published:2016 Issue:23 Volume:14 Page:5263-5271
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Ghosh Arun K.¹²³⁴,Lv Kai¹²³⁴,Ma Nianchun¹²³⁴,Cárdenas Emilio L.¹²³⁴,Effenberger Kerstin A.⁵⁶⁷⁴,Jurica Melissa S.⁵⁶⁷⁴

Affiliation:

1. Department of Chemistry and Department of Medicinal Chemistry

2. Purdue University

3. West Lafayette

4. USA

5. Department of Molecular Cell and Developmental Biology and Center for Molecular Biology of RNA

6. University of California

7. Santa Cruz

Abstract

Enantioselective syntheses of the desmethyl and carba-derivatives of herboxidiene and their biological evaluation in splicing assay are reported.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB00725B

Reference40 articles.

1. Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation

2. An extensive network of coupling among gene expression machines

3. Assembly of ribosomes and spliceosomes: complex ribonucleoprotein machines

4. Targeting the spliceosome

5. Split genes and RNA splicing

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