Photoactivatable prodrug for simultaneous release of mertansine and CO along with a BODIPY derivative as a luminescent marker in mitochondria: a proof of concept for NIR image-guided cancer therapy-Reference-Cited by-同舟云学术

Photoactivatable prodrug for simultaneous release of mertansine and CO along with a BODIPY derivative as a luminescent marker in mitochondria: a proof of concept for NIR image-guided cancer therapy

Published:2021 Issue:7 Volume:12 Page:2667-2673
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Tiwari Rajeshwari¹²³⁴⁵,Shinde Prashant S.⁶⁷³,Sreedharan Sreejesh⁸⁹¹⁰¹¹^ORCID,Dey Anik Kumar¹²³⁴⁵,Vallis Katherine A.⁸⁹¹⁰¹¹^ORCID,Mhaske Santosh B.⁶⁷³⁴⁵^ORCID,Pramanik Sumit Kumar¹²³⁴⁵^ORCID,Das Amitava¹²¹³³^ORCID

Affiliation:

1. Central Salt and Marine Chemicals Research Institute

2. Bhavnagar

3. India

4. Academy of Scientific and Innovative Research (AcSIR)

5. Ghaziabad 201002

6. CSIR-National Chemical Laboratory

7. Pune 411008

8. Oxford Institute for Radiation Oncology

9. University of Oxford

10. Oxford OX3 7DQ

11. UK

12. Indian Institute of Science Education and Research Kolkata

13. Mohanpur 741246

Abstract

Simultaneous release of two therapeutic reagents, mertansine and CO through photo-induced cleavage of a mitochondria-specific prodrug with improved drug efficacy.

Funder

Science and Engineering Research Board

Department of Biotechnology, Ministry of Science and Technology, India

Department of Science and Technology, Ministry of Science and Technology, India

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D0SC06270G

Reference41 articles.

1. Metabolism and Toxicity of Drugs. Two Decades of Progress in Industrial Drug Metabolism