Abstract
We report on the latest advancements in Microcrystal Electron Diffraction (3D ED/MicroED), as discussed during a symposium at the National Center for CryoEM Access and Training housed at the New York Structural Biology Center. This snapshot describes cutting-edge developments in various facets of the field and identifies potential avenues for continued progress. Key sections discuss instrumentation access, research applications for small molecules and biomacromolecules, data collection hardware and software, data reduction software, and finally reporting and validation. 3D ED/MicroED is still early in its wide adoption by the structural science community with ample opportunities for expansion, growth, and innovation.
Funder
National Institutes of Health, National Institute of General Medical Sciences
National Science Foundation
National Institutes of Health, Common Fund Transformative High Resolution Cryo-Electron Microscopy program
Simons Foundation
National Institutes of Health, National Cancer Institute
Sloan Kettering Institute
Biotechnology and Biological Sciences Research Council
EU H2020 ITN project NanED
Publisher
International Union of Crystallography (IUCr)
Cited by
4 articles.
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1. An Updated Structure of Oxybutynin Hydrochloride;Advanced Science;2024-09-03
2. Microcrystal Electron Diffraction（MicroED, 3D ED）for Small-Molecule Crystals;Nihon Kessho Gakkaishi;2024-08-31
3. Data collection is your last experiment;Acta Crystallographica Section C Structural Chemistry;2024-06-14
4. 3D ED/MicroED entering a new era;Acta Crystallographica Section C Structural Chemistry;2024-05-31