Physical exertion worsens symptoms in patients with post-COVID condition

Author:

Breedveld Ellen1,Charlton Braeden1,Appelman Brent2,Biere-Rafi Sara3,Janssen Kasper4,van Vugt Michèle5,Wüst Rob C.I.1ORCID

Affiliation:

1. Faculty of Behavioral and Movement Sciences, VU University Amsterdam, Amsterdam

2. Center for Experimental and Molecular Medicine, Department of Infectious Diseases, Amsterdam UMC location AMC, Amsterdam

3. Department of Medical and Scientific Affairs, C-support, ’s Hertogenbosch, The Netherlands

4. DeSportarts Utrecht, Department of Sports and Lifestyle Medicine, Julius Health Centers, Leidsche Rijn Center, Utrecht

5. Department of Infectious Diseases and Tropical Medicine, Amsterdam UMC location AMC, Amsterdam

Abstract

Patients with post-COVID condition suffer from fatigue, limited exercise capacity, and post-exertional malaise. Post-exertional malaise is the worsening of symptoms after physical or mental exertion, which reduces the efficacy of most forms of rehabilitation. This article presents the current understanding in the pathophysiology of post-COVID condition, particularly the underlying causes of post-exertional malaise.

Publisher

ScienceOpen

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