Pharmacotherapeutic efficacy of the use of pelargonium sidovid root extract in the prevention and treatment of respiratory diseases

Abstract

Relevance in research infectious and inflammatory diseases of the upper respiratory tract caused by high prevalence, variability of clinical manifestations and severity of the disease with the risk of developing complications. Respiratory diseases are a cause of functional and morphological disorders of the respiratory tract mucosa which is a protective barrier against various damaging agents. It is necessary to use complex drugs that preserve and restore the physiological activity of the mucous membrane as much as possible. In this regard, there is a great interest of plant medical product (extract of the roots of pelargonium sidovid is the chief active ingredient) which causes stimulation of nonspecific protective mechanisms, the beating frequency of the cilia of the ciliated epithelium, the activity of NK cells, phagocytes, modulation of the synthesis of interferon and proinflammatory cytokines, the expression of adhesive molecules, chemotaxis. We can notice moderate direct antibacterial and antiviral properties of extract. The pharmacotherapeutic efficacy of the plant medical product containing an extract of pelargonium sidovid roots was analysed in our research to treatment of respiratory diseases. There is a literature review about efficacy and safety preparations containing liquid extract of pelargonium sidovid roots. The extract effectiveness is confirmed by the results of clinical investigation: children and adults are digest the drug, greatly facilitates the course of diseases, prevents the development of complications, and reduces the duration of acute respiratory infections. Extract of the roots of pelargonium sidovid is easy to use and dosage. All these properties make it possible to include this medical product in the complex therapy of inflammatory diseases of the respiratory tract.