Affiliation:
1. Kuban State Medical University; Krasnodar Regional Centre of Family Health Protection and Reproduction
2. Kuban State Medical University
Abstract
Introduction. Chronic endometritis complicates infertility management that sets the task of searching new approaches of treatment. Special attention is paid to the use of enzymatic drugs that improve repair processes. Аim. Тo evaluate the effect of the bovgialuronidasa azoxymer on the restoration of the morphofunctional state of the endometrium and receptor apparatus in infertile women with chronic endometritis. Materials and methods. Forty-seven reproductive age women who applied for infertility with chronic endometritis were examined. The general, somatic, and gynecological history assessment has been carried out. Complaints included the pain syndrome (100 %), discharge from the genital tract (100 %), and the pain during palpation and uterine traction (89.4 %). Paipel-biopsy was carried out with subsequent morphological and cultural study of the endometrium. The immunohistochemical analysis was carried out, and endometrial receptivity was studied. The middle M-echo was detected. Statistical processing was carried out using the Microsoft Exel application package (2010), STATISTICA 13.3 (USA, Tibco). Results. Diagnostic measures including cultural and morphological examination of the endometrium allows to verify chronic endometritis. The use of this protocol allows half of infertile women with chronic endometritis to achieve pregnancy. The use of bovgialuronidasa azoxymer increases rate of pregnancy on 23.9 %. Conclusion. Treatment under this protocol allows half of the patients with infertility due to chronic endometritis, including autoimmune one, to achieve pregnancy.
Reference10 articles.
1. Radzinskii V. E. Khronicheskii endometrit. Sovremennye aspekty / V. E. Radzinskii, Yu. A. Petrov, M. L. Polina // Kubanskii nauchnyi meditsinskii vestnik. – 2017. – (5): 69–74. https://doi.org/10.25207/1608-6228-2017-24-5-69-74. – Radzinsky V. E., Petrov Yu. A., Polina M. L. Chronic endometritis: current aspects. Kuban Scientific Medical Bulletin. 2017; (5): 69–74. (In Russ.) https://doi.org/10.25207/1608-6228-2017-24-5-69-74.
2. Ozdoeva I. M.-B. Khronicheskii endometrit: izmeneniya osnovnykh zven'ev immuniteta / I. M.-B. Ozdoeva, Yu. A. Petrov // Mezhdunarodnyi zhurnal prikladnykh i fundamental'nykh issledovanii. – 2020. – (4): 26–30. Rezhim dostupa: https://applied-research.ru/ru/article/view?id=13050. – Ozdoeva I. M.-B., Petrov Yu. A. Chronic endometritis: changes in the main links of immunity. International Journal of Applied and Basic Research. 2020; (4): 26–30. (In Russ.) Available at: https://applied-research.ru/ru/article/view?id=13050.
3. Cicinelli E., Matteo M., Tinelli R., Lepera A., Alfonso R., Indraccolo U. et al. Resta Prevalence of chronic endometritis in reapeted unexplained implantation failure and the IVF success rate after antibiotic therapy. Hum Reprod. 2014; 30 (2): 323–330. https://doi.org/10.1093/humrep/deu292.
4. Manukhin I. B. Khronicheskii endometrit i nevynashivanie beremennosti / I. B. Manukhin [i dr.] // Meditsinskii sovet. – 2018. – (7): 45–49. https://doi.org/10.21518/2079-701X-2018-7-46-49. – Manukhin, I. B., Sementsova N. A., Mitrofanova Yu. Yu., Livshits L. Yu. Chronic endometritis and habitual miscarriage. Meditsinskiy Sovet. 2018; (7): 45–49. (In Russ.) https://doi.org/10.21518/2079-701X-2018-7-46-49.
5. Marchenko L. A. Klinicheskie i mikrobiologicheskie aspekty khronicheskogo endometrita u zhenshchin reproduktivnogo vozrasta / L. A. Marchenko [i dr.] // Antibiotiki i khimioterapiya. – 2016. – (2): 45–52. Rezhim dostupa: https://www.antibiotics-chemotherapy.ru/jour/article/view/686. – Marchenko L. A., Chernukha G. E., Yakushevskaya O. V., Gombolevskaya N. A., Muravieva V. V., Priputnevich T. V., Ankirskaya A. S. Clinical and Microbiological Aspects of Chronic Endometritis in Women of Reproductive Age. Antibiotiki i Khimioterapiya. 2016; (2): 45–52. (In Russ.) Available at: https://www.antibiotics-chemotherapy.ru/jour/article/view/686.