Respimat as the new standard for inhalation therapy devices-Reference-Cited by-同舟云学术

Respimat as the new standard for inhalation therapy devices

Published:2021-10-29 Issue:16 Volume: Page:32-37
ISSN:2658-5790
Container-title:Meditsinskiy sovet = Medical Council
language:
Short-container-title:Medicinskij sovet

Author:

Arkhipov V. V.¹^ORCID

Affiliation:

1. Russian Medical Academy of Continuous Professional Education

Abstract

The effectiveness of inhalation therapy can be significantly reduced by a number of problems. For example, inhalation technique errors can reduce the dose delivered by 22-95% compared to the optimal value in patients with technical errors in the use of the inhaler. Sub-optimal inspiratory flow rates in a number of patients with chronic obstructive pulmonary disease and asthma are often the cause of technical errors during inhalation. Patient education does not produce the expected results, as the underlying cause of reduced flow is high hyperinflation and weakening of the respiratory musculature. The use of technologically outdated inhalers is another significant cause of reduced therapy effectiveness. Patient education and even conversion to a different inhaler do not always increase the effectiveness of therapy. Respimat, a brand new delivery agent introduced in 2004, allows 39% to 67% of the nominal dose to be delivered to the airways, while the degree of pulmonary deposit is independent of inspiratory flow and pulmonary drug deposit does not decrease with increasing obstruction. Compared to powder inhalers, Respimat creates less resistance to airflow on inhalation. In addition, Respimat is an active device that requires no effort on the part of the patient to move the aerosol particles. These features make Respimat the new standard for inhalation therapy. This review aims to familiarise readers with the main features of the Respimat and the latest research findings

Publisher

Remedium, Ltd.

Subject

General Medicine

Reference34 articles.

1. Rootmensen G.N., van Keimpema A.R., Looysen E.E., van der Schaaf L., Jansen H.M., de Haan R.J. Reliability in the Assessment of Videotaped Inhalation Technique. J Aerosol Med. 2007;20(4):429–433. https://doi.org/10.1089/jam.2007.0623.

2. Sanchis J., Gich I., Pedersen S. Systematic Review of Errors in Inhaler Use: Has Patient Technique Improved Over Time? Chest. 2016;150(2):394–406. https://doi.org/10.1016/j.chest.2016.03.041.

3. Price D.B., Thomas V., Richard Dekhuijzen P.N., Bosnic-Anticevich S., Roche N., Lavorini F. et al. Evaluation of Inhaler Technique and Achievement and Maintenance of Mastery of Budesonide/Formoterol Spiromax® Compared with Budesonide/Formoterol Turbuhaler® in Adult Patients with Asthma: the Easy Low Instruction Over Time (ELIOT) study. BMC Pulm Med. 2018;18(1):107. https://doi.org/10.1186/s12890-018-0665-x.

4. Ding N., Zhang W., Wang Z., Bai C., He Q., Dong Y. et al. Prevalence and Associated Factors of Suboptimal Daily Peak Inspiratory Flow and Technique Misuse of Dry Powder Inhalers in Outpatients with Stable Chronic Airway Diseases. Int J Chron Obstruct Pulmon Dis. 2021;16:1913–1924. https://doi.org/10.2147/COPD.S311178.

5. Aisanov Z.R., Arkhipov V.V., Avdeev S.N., Antonov V.N., Demko I.V., Zhestkov А.V. et al. Suboptimal Peak Inspiratory Flow Rate in COPD Patients: the Importance of Assessment in Clinical Practice. Expert Council Consensus. Pulmonologiya = Russian Pulmonology. 2020;30(6):805–811. https://doi.org/10.18093/0869-0189-2020-30-6-805-811.