Features of inflammatory eye damage in autoimmune rheumatic diseases (clinical observations)

Abstract

Immuno-inflammatory rheumatic diseases (RD) represent a wide range of genetic and non-genetic clinically heterogeneous inflammatory diseases characterized by a combination of autoinflammatory and autoimmune and autoimmune processes. In most cases, these diseases are accompanied by extra-articular manifestations, the most common of which are inflammatory diseases of the eye o, which can occur within a few years after the diagnosis of the underlying systemic disease, and in some cases, RD may debut with ocular pathology. The article presents clinical examples demonstrating the features of eye damage in some rheumatic diseases, such as spondyloarthritis-associated chronic anterior uveitis (SpA), chronic recurrent scleritis, episcleritis, scleromalacia and acute anterior uveitis in rheumatoid arthritis (RA), granulomatous scleral inflammatory masses with ulceration in granulomatosis with polyangiitis (HPA) (Wegener's granulomatosis), verified in the Federal State Budgetary Research University named after V.A. Nasonova. The described conditions were successfully treated by instillations of glu-cocorticosteroids and nonsteroidal anti-inflammatory drugs (NSAIDs), parabulbar injections of corticosteroids, as well as the systemic use of NSAIDs. In the case of HPA, systemic therapy with corticosteroids and cytostatics was additionally performed. Knowledge of eye symptoms plays an important role in the diagnosis of systemic immunoinflammatory rheumatic diseases, as well as in prescribing correct and timely therapy with the multidisciplinary approach.