A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1-Reference-Cited by-同舟云学术

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A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1

Published:2007-10-28 Issue:12 Volume:13 Page:1490-1495
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Piontek Klaus,Menezes Luis F,Garcia-Gonzalez Miguel A,Huso David L,Germino Gregory G

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/nm1675.pdf

Reference30 articles.

1. Boucher, C. & Sandford, R. Autosomal dominant polycystic kidney disease (ADPKD, MIM 173900, PKD1 and PKD2 genes, protein products known as polycystin-1 and polycystin-2). Eur. J. Hum. Genet. 12, 347–354 (2004).

2. Pretorius, D.H. et al. Diagnosis of autosomal dominant polycystic kidney disease in utero and in the young infant. J. Ultrasound Med. 6, 249–255 (1987).

3. Piontek, K.B. et al. A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo. J. Am. Soc. Nephrol. 15, 3035–3043 (2004).

4. Lu, W. et al. Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation. Nat. Genet. 17, 179–181 (1997).

5. Bukanov, N.O., Smith, L.A., Klinger, K.W., Ledbetter, S.R. & Ibraghimov-Beskrovnaya, O. Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine. Nature 444, 949–952 (2006).

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