Integration of genome-scale metabolic networks into whole-body PBPK models shows phenotype-specific cases of drug-induced metabolic perturbation-Reference-Cited by-同舟云学术

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Integration of genome-scale metabolic networks into whole-body PBPK models shows phenotype-specific cases of drug-induced metabolic perturbation

Published:2018-02-26 Issue:1 Volume:4 Page:
ISSN:2056-7189
Container-title:npj Systems Biology and Applications
language:en
Short-container-title:npj Syst Biol Appl

Author:

Cordes Henrik,Thiel Christoph,Baier Vanessa,Blank Lars M.,Kuepfer Lars

Publisher

Springer Science and Business Media LLC

Subject

Applied Mathematics,Computer Science Applications,Drug Discovery,General Biochemistry, Genetics and Molecular Biology,Modeling and Simulation

Link

http://www.nature.com/articles/s41540-018-0048-1.pdf

Reference60 articles.

1. Moore, T. J., Cohen, M. R. & Furberg, C. D. Serious adverse drug events reported to the Food and Drug Administration, 1998–2005. Arch. Intern. Med. 167, 1752–1759 (2007).

2. Abboud, G. & Kaplowitz, N. Drug-induced liver injury. Drug Saf. 30, 277–294 (2007).

3. Kaplowitz, N. Biochemical and cellular mechanisms of toxic liver injury. Semin. Liver Dis. 22, 137–144 (2002).

4. Kaplowitz, N. Drug-induced liver injury. Clin. Infect. Dis. 38, S44–S48 (2004).

5. Kleiner, D. The pathology of drug-induced liver injury. Semin. Liver Dis. 29, 364–372 (2009).

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