The mechanism of γ-Secretase dysfunction in familial Alzheimer disease-Reference-Cited by-同舟云学术

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

Published:2012-04-13 Issue:10 Volume:31 Page:2261-2274
ISSN:0261-4189
Container-title:The EMBO Journal
language:en
Short-container-title:

Author:

Chávez-Gutiérrez Lucía¹²,Bammens Leen¹²,Benilova Iryna¹²,Vandersteen Annelies³⁴,Benurwar Manasi¹²,Borgers Marianne¹²,Lismont Sam¹²,Zhou Lujia¹²,Van Cleynenbreugel Simon¹²,Esselmann Hermann⁵,Wiltfang Jens⁵,Serneels Lutgarde¹²,Karran Eric²,Gijsen Harrie⁶,Schymkowitz Joost⁷,Rousseau Frederic⁴⁷,Broersen Kerensa³⁸,De Strooper Bart¹²

Affiliation:

1. VIB Center for the Biology of Disease; Leuven Belgium

2. Center for Human Genetics (CME) and Leuven Institute for Neurodegenerative Diseases (LIND), University of Leuven (KUL); Leuven Belgium

3. Faculty of Science and Technology, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente; AE Enschede The Netherlands

4. Switch Laboratory, Department of Cellular and Molecular Medicine, KULeuven; Leuven Belgium

5. Department of Psychiatry and Psychotherapy, LVR-Clinics Essen, University of Duisburg-Essen; Essen Germany

6. Janssen Research & Development, a Division of Janssen Pharmaceutica NV; Beerse Belgium

7. VIB Switch Laboratory, Flanders Institute for Biotechnology (VIB); Leuven Belgium

8. Vrije Universiteit Brussel; Brussel Belgium

Publisher

Wiley

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

Reference68 articles.

1. Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins;Annaert;Neuron,2001

2. Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons;Annaert;J Cell Biol,1999

3. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms;Bentahir;J Neurochem,2006

4. Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein;Berezovska;J Neurosci,2005

5. Gamma-secretases: from cell biology to therapeutic strategies;Bergmans;Lancet Neurol,2010

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