γ-Secretase, notch, Aβ and alzheimer's disease: Where do the presenilins fit in?
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Neuroscience
Link
http://www.nature.com/articles/nrn785.pdf
Reference137 articles.
1. Price, D. L. & Sisodia, S. S. Mutant genes in familial Alzheimer's disease and transgenic models. Annu. Rev. Neurosci. 21, 479–505 (1998).
2. Schenk, D. et al. Immunization with Aβ attenuates Alzheimer's disease-like pathology in the PDAPP mouse. Nature 400, 173–177 (1999).
3. Bard, F. et al. Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nature Med. 6, 916–919 (2000).
4. Janus, C. et al. Aβ-immunization reduces behavioural impairment and dense-cored plaques in a model of Alzheimer's disease. Nature 408, 979–982 (2000).
5. Morgan, D. et al. Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature 408, 982–985 (2000).References 2–5 describe the use of Aβ peptides as a vaccine to generate antibodies that facilitate the clearance of Alzheimer's-disease-like neuropathology and cognitive deficits in transgenic mouse models of Alzheimer's disease.
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