Gemcitabine triggers a pro-survival response in pancreatic cancer cells through activation of the MNK2/eIF4E pathway-Reference-Cited by-同舟云学术

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Gemcitabine triggers a pro-survival response in pancreatic cancer cells through activation of the MNK2/eIF4E pathway

Published:2012-07-16 Issue:23 Volume:32 Page:2848-2857
ISSN:0950-9232
Container-title:Oncogene
language:en
Short-container-title:Oncogene

Author:

Adesso L,Calabretta S,Barbagallo F,Capurso G,Pilozzi E,Geremia R,Delle Fave G,Sette C

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Genetics,Molecular Biology

Link

http://www.nature.com/articles/onc2012306.pdf

Reference32 articles.

1. Kern SE, Shi C, Hruban RH . The complexity of pancreatic ductal cancers and multidimensional strategies for therapeutic targeting. J Pathol 2011; 223: 295–306.

2. Falasca M, Selvaggi F, Buus R, Sulpizio S, Edling CE . Targeting phosphoinositide 3-kinase pathways in pancreatic cancer--from molecular signaling to clinical trials. Anticancer Agents Med Chem 2011; 11: 455–463.

3. Sun SY, Rosenberg LM, Wang X, Zhou Z, Yue P, Fu H et al. Activation of Akt and eIF4E survival pathways by rapamycin mediated mammalian target of rapamycin inhibition. Cancer Res 2005; 65: 7052–7058.

4. Wang X, Yue P, Chan C, Ye K, Ueda T, Watanabe-Fukunaga R et al. Inhibition of Mammalian Target of Rapamycin Induces Phosphatidylinositol 3-Kinase Dependent and Mnk-Mediated Eukaryotic Translation Initiation Factor 4E Phosphorylation. Mol Cell Biol 2007; 27: 7405–7413.

5. Zoncu R, Efeyan A, Sabatini DM . mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011; 12: 21–35.

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