Benzodiazepines act on GABAA receptors via two distinct and separable mechanisms
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Neuroscience
Link
http://www.nature.com/articles/nn1200_1274.pdf
Reference45 articles.
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3. Sigel, E. & Buhr, A. The benzodiazepine binding site of GABA-A receptors. Trends Pharmacol. Sci. 18, 425–429 (1997).
4. Wieland, H. A., Luddens, H. & Seeburg, P. H. A single histidine in GABAA receptors is essential for benzodiazepine agonist binding. J. Biol. Chem. 267, 1426–1429 (1992).
5. Amin, J., Brooks-Kayal, A. & Weiss, D. S. Two tyrosine residues on the αsubunit are crucial for benzodiazepine binding and allosteric modulation of the γ-aminobutyric acid A receptors. Mol. Pharmacol. 51, 833–841 (1997).
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