1. 1. Belote, J. M. & Lucchesi, J. C. Control of X chromosome transcription by the maleless gene in Drosophila. Nature 285, 573-575 (1980). 2. Baker, B. S., German, M. & Marin, I.I Dosage compensation in Drosophila. Annu. Rev. Genet. 28, 491-521 (1994). 3. Hilfiker, A., Hilfiker-Kleiner, D., Pannuti, A. & Lucchesi, J. C. mof, a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in Drosophila. EMBO J. 16, 2054-2060 (1997). 4. Kelley, R. L. et al. Expresison of Msl-2 causes assembly of dosage compensation regulators on the X chromosomes and female lethality in Drosophila. Cell 81, 867-877 (1995). 5. Cline, T. W. Autoregulatory functioning of a Drosophila gene product that establishes and maintains the sexually determined state. Genetics 107, 231-277 (1984). 6. Lucchesi, J. C. & Skripsky, T. The link between dosage compensation and sex differentiation in Drosophila melanogaster. Chromosoma 82, 217-227 (1981). 7. Zhou, S. et al. Male-specific-lethal 2, a dosage compensation gene of Drosophila that undergoes sex-specific regulation and encodes a protein with a RING finger and a metallothionein-like cluster. EMBOJ. 14, 2884-2895 (1995). 8. Bashaw, G. J. & Baker, B. S. The msl2 dosage compensation gene of Drosophila encodes a putative DNA-binding protein whose expression is sex specifically regulated by Sex-lethal. Development 121, 3245-3258 (1995). 9. Bell, L. R., Horabin, J. L, Schedl, P. & Cline, T. W. Positive autoregulation of Sex-lethal by alternative splicing maintains the female determined state in Drosophila. Cell 665, 229-239 (1991). 10. Sosnowski, B. A., Belote, J. M. & McKeown, M. Sex-specific alternative splicing of RNA from the transformer gene results from sequence-dependent splice site blockage. Cell 58, 449-459 (1989). 11. Samuels, M. E. et al. RNA binding by Sxl proteins in vitro and in vivo. Mol. Cell. Biol. 14, 4975-4990 (1994). 12. Kozak, M. Structural features in eukaryotic mRNAs that modulate the initiation of translation. /. Biol. Chem. 266, 19867-19870 (1991). 13. Geballe, A. P. & Morris, D. R. Initiation codons within 5'-leaders of mRNAs as regulators of translation. Trends Biochem. Sri. 19, 159-164 (1994). 14. Oh, S.-K., Scott, M. P. & Sarnow, P. Homeotic gene Antennapedia mRNA contains 5'-noncoding sequences that confer translational initiation by internal ribosome binding. Genes Dev. 6, 1643-1653 (1992). 15. Palmer, M. J. et al. The male specific lethal-one gene encodes a novel protein that associates with the male X chromosome in Drosophila. Genetics 134, 545-557 (1993). 16. Palmer, M. J., Richman, R., Richter, L. & Kuroda, M. I. Sex-specific regulation of the male-specific lethal-1 dosage compensation gene in Drosophila. Genes Dev. 8, 698-706 (1994). 17. Guru's, D., Lehmann, R. & Zamore, P. D. Translational regulation in development. Cell 81,171-178 (1995). 18. Caughman, S. W., Hentze, M. W., Rouault, T. A., Harford, J. B. & Klausner, R. D. The iron-responsive element is the single element responsible for iron-dependent translational regulation of ferritin biosynthesis. Evidence for function as the binding site for a translational repressor. /. Biol. Chem. 263, 19048-19052 (1988). 19. Tarun, S. Z. & Sachs, A. B. Association of the yeast poly(A) tail binding protein with translation initiation factor eIF-4G. EMBO J. 15, 7168-7177 (1996). 20. Kelley, R. L. & Kuroda, M. I. Equality for X chromosomes. Science 270, 1607-1610 (1995). 21. Pirrotta, V. in Vectors: A Survey of Molecular Cloning Vectors and Their Uses (eds Rodriguez, R. L. & Denhardt, D. T.) 437-456 (Butterworths, Boston, 1988). 22. Wang, J. & Bell, L. R. The Sex-lethal amino terminus mediates cooperative interactions in RNA binding and is essential for splicing regulation. Genes Dev. 8, 2072-2085 (1994). 23. Higuchi, R., Krummel, B. & Saiki, R. K. A general method of in vitro preparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions. Nucleic Acids Res. 16, 7351-7367(1988). 24. Rubin, G. M. & Spradling, A. C. Genetic transformation of Drosophila with transposable element vectors. Science 218, 348-353 (1982). 25. Bone, J. R. et al. Acetylated histone H4 on the male X chromosome is associated with dosage compensation in Drosophila. Genes Dev. 8, 96-104 (1994).