Abstract
AbstractAging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related diseases leading to increased mortality. By comparing the relationship between age and elastin turnover with healthy volunteers, we show that accelerated elastin turnover by age-disease interaction is a common feature of age-related diseases.
Funder
Heart Research UK
Chief Scientist Office
Pfizer
RCUK | Medical Research Council
Publisher
Springer Science and Business Media LLC
Reference29 articles.
1. Chang, A. Y., Skirbekk, V. F., Tyrovolas, S., Kassebaum, N. J. & Dieleman, J. L. Measuring population ageing: an analysis of the Global Burden of Disease Study 2017. Lancet Public Health 4, e159–e167 (2019).
2. Harris, R. E. Epidemiology of chronic disease: global perspectives. (Jones & Bartlett Learning, 2019).
3. MacNee, W., Rabinovich, R. A. & Choudhury, G. Ageing and the border between health and disease. Eur. Respir. J. 44, 1332–1352 (2014).
4. Lopez-Otin, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. The hallmarks of aging. Cell 153, 1194–1217 (2013).
5. Toyama, B. H. & Hetzer, M. W. Protein homeostasis: live long, won’t prosper. Nat. Rev. Mol. Cell Biol. 14, 55–61 (2013).
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