The colchicine derivative CT20126 shows a novel microtubule-modulating activity with apoptosis

Author:

Kim Sung-Kuk,Cho Sang-Min,Kim Ho,Seok Heon,Kim Soon-Ok,Kyu Kwon Taeg,Chang Jong-Soo

Publisher

Springer Science and Business Media LLC

Subject

Clinical Biochemistry,Molecular Biology,Molecular Medicine,Biochemistry

Reference34 articles.

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2. Hadfield JA, Ducki S, Hirst N, McGown AT . Tubulin and microtubules as targets for anticancer drugs. Prog Cell Cycle Res 2003; 5: 309–325.

3. Tian W, Qin L, Song Q, He L, Ai M, Jin Y et al. A novel synthetic analog of 5, 8-disubstituted quinazolines blocks mitosis and induces apoptosis of tumor cells by inhibiting microtubule polymerization. PLoS One 2010; 5: e10499.

4. Mohan R, Panda D . Kinetic stabilization of microtubule dynamics by estramustine is associated with tubulin acetylation, spindle abnormalities, and mitotic arrest. Cancer Res 2008; 68: 6181–6189.

5. Gajate C, Barasoain I, Andreu JM, Mollinedo F . Induction of apoptosis in leukemic cells by the reversible microtubule-disrupting agent 2-methoxy-5-(2′,3′,4′-trimethoxyphenyl)-2,4,6-cycloheptatrien-1-one: protection by Bcl-2 and Bcl-X(L) and cell cycle arrest. Cancer Res 2000; 60: 2651–2659.

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