Genome-wide association study of musical beat synchronization demonstrates high polygenicity
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Published:2022-06-16
Issue:9
Volume:6
Page:1292-1309
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ISSN:2397-3374
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Container-title:Nature Human Behaviour
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language:en
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Short-container-title:Nat Hum Behav
Author:
Niarchou MariaORCID, Gustavson Daniel E.ORCID, Sathirapongsasuti J. Fah, Anglada-Tort ManuelORCID, Eising ElseORCID, Bell Eamonn, McArthur EvonneORCID, Straub Peter, Aslibekyan Stella, Auton Adam, Bell Robert K., Bryc Katarzyna, Clark Sarah K., Elson Sarah L., Fletez-Brant Kipper, Fontanillas Pierre, Furlotte Nicholas A., Gandhi Pooja M., Heilbron Karl, Hicks Barry, Huber Karen E., Jewett Ethan M., Jiang Yunxuan, Kleinman Aaron, Lin Keng-Han, Litterman Nadia K., McCreight Jey C., McIntyre Matthew H., McManus Kimberly F., Mountain Joanna L., Mozaffari Sahar V., Nandakumar Priyanka, Noblin Elizabeth S., Northover Carrie A. M., O’Connell Jared, Pitts Steven J., Poznik G. David, Shastri Anjali J., Shelton Janie F., Shringarpure Suyash, Tian Chao, Tung Joyce Y., Tunney Robert J., Vacic Vladimir, Wang Xin, McAuley J. DevinORCID, Capra John A.ORCID, Ullén Fredrik, Creanza Nicole, Mosing Miriam A., Hinds David A.ORCID, Davis Lea K.ORCID, Jacoby Nori, Gordon Reyna L.ORCID,
Abstract
AbstractMoving in synchrony to the beat is a fundamental component of musicality. Here we conducted a genome-wide association study to identify common genetic variants associated with beat synchronization in 606,825 individuals. Beat synchronization exhibited a highly polygenic architecture, with 69 loci reaching genome-wide significance (P < 5 × 10−8) and single-nucleotide-polymorphism-based heritability (on the liability scale) of 13%–16%. Heritability was enriched for genes expressed in brain tissues and for fetal and adult brain-specific gene regulatory elements, underscoring the role of central-nervous-system-expressed genes linked to the genetic basis of the trait. We performed validations of the self-report phenotype (through separate experiments) and of the genome-wide association study (polygenic scores for beat synchronization were associated with patients algorithmically classified as musicians in medical records of a separate biobank). Genetic correlations with breathing function, motor function, processing speed and chronotype suggest shared genetic architecture with beat synchronization and provide avenues for new phenotypic and genetic explorations.
Funder
U.S. Department of Health & Human Services | NIH | NIH Office of the Director U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences
Publisher
Springer Science and Business Media LLC
Subject
Behavioral Neuroscience,Experimental and Cognitive Psychology,Social Psychology
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