Harnessing a brain parasite as a tool for delivery of therapeutics to the brain
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Publisher
Springer Science and Business Media LLC
Link
https://www.nature.com/articles/s41564-024-01772-0.pdf
Reference5 articles.
1. Terstappen, G. C., Meyer, A. H., Bell, R. D. & Zhang, W. Strategies for delivering therapeutics across the blood–brain barrier. Nat. Rev. Drug Discov. 20, 362–383 (2021). A review of current approaches for delivery of therapeutics, particularly those that are protein-based, across the BBB.
2. Lodoen, M. B., Gerke, C. & Boothroyd, J. C. A highly sensitive FRET-based approach reveals secretion of the actin-binding protein toxofilin during Toxoplasma gondii infection. Cell. Microbiol. 12, 55–66 (2010). The first demonstration of toxofilin fusion driving secretion from the rhoptries.
3. Notin, P., Rollins, N., Gal, Y., Sander, C. & Marks, D. Machine learning for functional protein design. Nat. Biotechnol. 42, 216–228 (2024). A review of recent machine-learning techniques for protein design and engineering that will unlock new types of tools and therapeutics, requiring compatible delivery approaches.
4. Oladejo, M., Paterson, Y. & Wood, L. M. Clinical experience and recent advances in the development of Listeria-based tumor immunotherapies. Front. Immunol. 12, 642316 (2021). A paper describing the development of current Listeria-based immunotherapies and the gradual improvement of their safety profile by strain attenuation.
5. Bulcha, J. T., Wang, Y., Ma, H., Tai, P. W. L. & Gao, G. Viral vector platforms within the gene therapy landscape. Sig. Transduct. Target. Ther. 6, 53 (2021). A review of the history and development of viral vectors for gene therapy and their attenuation for improved safety and clinical application.
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