No association between cortical dopamine D2 receptor availability and cognition in antipsychotic-naive first-episode psychosis

Author:

Lee MariaORCID,Fatouros-Bergman Helena,Plavén-Sigray Pontus,Ikonen Victorsson Pauliina,Sellgren Carl M.,Erhardt Sophie,Flyckt Lena,Farde LarsORCID,Cervenka SimonORCID

Abstract

AbstractCognitive impairment is an important predictor of disability in schizophrenia. Dopamine neurotransmission in cortical brain regions has been suggested to be of importance for higher-order cognitive processes. The aim of this study was to examine the relationship between extrastriatal dopamine D2-R availability and cognitive function, using positron emission tomography and the high-affinity D2-R radioligand [11C]FLB 457, in an antipsychotic-naive sample of 18 first-episode psychosis patients and 16 control subjects. We observed no significant associations between D2-R binding in the dorsolateral prefrontal cortex or hippocampus (β = 0.013–0.074, partial r = −0.037–0.273, p = 0.131–0.841). Instead, using Bayesian statistics, we found moderate support for the null hypothesis of no relationship (BFH0:H1 = 3.3–8.2). Theoretically, our findings may suggest a lack of detrimental effects of D2-R antagonist drugs on cognition in schizophrenia patients, in line with clinical observations.

Funder

ALF Payment for Clinical Research

Svenska Sällskapet för Medicinsk Forskning

Lundbeckfonden

Vetenskapsrådet

Torsten Söderbergs Stiftelse

Publisher

Springer Science and Business Media LLC

Subject

Psychiatry and Mental health

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