Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase-Reference-Cited by-同舟云学术

Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase

Published:2024-04-24 Issue:8011 Volume:629 Page:435-442
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Baltgalvis Kristen A.,Lamb Kelsey N.,Symons Kent T.,Wu Chu-Chiao,Hoffman Melissa A.,Snead Aaron N.,Song Xiaodan,Glaza Thomas,Kikuchi Shota,Green Jason C.,Rogness Donald C.,Lam Betty,Rodriguez-Aguirre Maria E.^ORCID,Woody David R.,Eissler Christie L.,Rodiles Socorro,Negron Seth M.,Bernard Steffen M.,Tran Eileen,Pollock Jonathan,Tabatabaei Ali,Contreras Victor,Williams Heather N.,Pastuszka Martha K.,Sigler John J.,Pettazzoni Piergiorgio,Rudolph Markus G.^ORCID,Classen Moritz,Brugger Doris,Claiborne Christopher,Plancher Jean-Marc,Cuartas Isabel,Seoane Joan^ORCID,Burgess Laurence E.,Abraham Robert T.,Weinstein David S.,Simon Gabriel M.,Patricelli Matthew P.^ORCID,Kinsella Todd M.^ORCID

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s41586-024-07318-y.pdf

Reference40 articles.

1. Behan, F. M. et al. Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens. Nature 568, 511–516 (2019).

2. Chan, E. M. et al. WRN helicase is a synthetic lethal target in microsatellite unstable cancers. Nature 568, 551–556 (2019).

3. Kategaya, L., Perumal, S. K., Hager, J. H. & Belmont, L. D. Werner syndrome helicase is required for the survival of cancer cells with microsatellite instability. iScience 13, 488–497 (2019).

4. Lieb, S. et al. Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells. eLife 8, e43333 (2019).

5. van Wietmarschen, N. et al. Repeat expansions confer WRN dependence in microsatellite-unstable cancers. Nature 586, 292–298 (2020).

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