The landscape of somatic mutation in normal colorectal epithelial cells

Author:

Lee-Six Henry,Olafsson Sigurgeir,Ellis Peter,Osborne Robert J.,Sanders Mathijs A.,Moore Luiza,Georgakopoulos Nikitas,Torrente Franco,Noorani Ayesha,Goddard Martin,Robinson Philip,Coorens Tim H. H.,O’Neill Laura,Alder Christopher,Wang Jingwei,Fitzgerald Rebecca C.,Zilbauer Matthias,Coleman Nicholas,Saeb-Parsy Kourosh,Martincorena Inigo,Campbell Peter J.,Stratton Michael R.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference59 articles.

1. Fearon, E. R. & Vogelstein, B. A genetic model for colorectal tumorigenesis. Cell 61, 759–767 (1990).

2. Alexandrov, L. B. et al. The repertoire of mutational signatures in human cancer. Preprint at https://www.biorxiv.org/content/10.1101/322859v2 (2019).

3. Sabarinathan, R. et al. The whole genome panorama of cancer drivers. Preprint at https://www.biorxiv.org/content/10.1101/190330v2 (2017).

4. Blokzijl, F. et al. Tissue-specific mutation accumulation in human adult stem cells during life. Nature 538, 260–264 (2016).

5. Roerink, S. F. et al. Intra-tumour diversification in colorectal cancer at the single-cell level. Nature 556, 457–462 (2018).

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