The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis-Reference-Cited by-同舟云学术

The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis

Published:2020-04-08 Issue:7804 Volume:580 Page:530-535
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Xu Daqian,Wang Zheng,Xia Yan,Shao Fei,Xia Weiya,Wei Yongkun,Li Xinjian,Qian Xu,Lee Jong-Ho,Du Linyong,Zheng Yanhua,Lv Guishuai,Leu Jia-shiun,Wang Hongyang,Xing Dongming,Liang Tingbo,Hung Mien-Chie,Lu Zhimin^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41586-020-2183-2.pdf

Reference36 articles.

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2. Röhrig, F. & Schulze, A. The multifaceted roles of fatty acid synthesis in cancer. Nat. Rev. Cancer 16, 732–749 (2016).

3. Feramisco, J. D., Goldstein, J. L. & Brown, M. S. Membrane topology of human Insig-1, a protein regulator of lipid synthesis. J. Biol. Chem. 279, 8487–8496 (2004).

4. Yabe, D., Brown, M. S. & Goldstein, J. L. Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Proc. Natl Acad. Sci. USA 99, 12753–12758 (2002).

5. Radhakrishnan, A., Ikeda, Y., Kwon, H. J., Brown, M. S. & Goldstein, J. L. Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig. Proc. Natl Acad. Sci. USA 104, 6511–6518 (2007).

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