Whole-genome doubling confers unique genetic vulnerabilities on tumour cells
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
https://www.nature.com/articles/s41586-020-03133-3.pdf
Reference54 articles.
1. Lens, S. M. A. & Medema, R. H. Cytokinesis defects and cancer. Nat. Rev. Cancer 19, 32–45 (2019).
2. Fujiwara, T. et al. Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. Nature 437, 1043–1047 (2005).
3. Ganem, N. J., Godinho, S. A. & Pellman, D. A mechanism linking extra centrosomes to chromosomal instability. Nature 460, 278–282 (2009).
4. Thompson, D. A., Desai, M. M. & Murray, A. W. Ploidy controls the success of mutators and nature of mutations during budding yeast evolution. Curr. Biol. 16, 1581–1590 (2006).
5. Dewhurst, S. M. et al. Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution. Cancer Discov. 4, 175–185 (2014).
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