Small-molecule-induced polymerization triggers degradation of BCL6-Reference-Cited by-同舟云学术

Small-molecule-induced polymerization triggers degradation of BCL6

Published:2020-11-18 Issue:7836 Volume:588 Page:164-168
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Słabicki Mikołaj^ORCID,Yoon Hojong^ORCID,Koeppel Jonas^ORCID,Nitsch Lena,Roy Burman Shourya S.^ORCID,Di Genua Cristina,Donovan Katherine A.^ORCID,Sperling Adam S.,Hunkeler Moritz^ORCID,Tsai Jonathan M.,Sharma Rohan,Guirguis Andrew^ORCID,Zou Charles,Chudasama Priya,Gasser Jessica A.,Miller Peter G.,Scholl Claudia^ORCID,Fröhling Stefan^ORCID,Nowak Radosław P.^ORCID,Fischer Eric S.^ORCID,Ebert Benjamin L.^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41586-020-2925-1.pdf

Reference45 articles.

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2. Lu, G. et al. The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins. Science 343, 305–309 (2014).

3. Krönke, J. et al. Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS. Nature 523, 183–188 (2015).

4. Huang, H.-T. et al. A chemoproteomic approach to query the degradable kinome using a multi-kinase degrader. Cell Chem. Biol. 25, 88–99 (2018).

5. McCoull, W. et al. Development of a novel B-cell lymphoma 6 (BCL6) PROTAC to provide insight into small molecule targeting of BCL6. ACS Chem. Biol. 13, 3131–3141 (2018).

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