Exploiting hosts and vectors: viral strategies for facilitating transmission

Author:

Yu Xi,Zhu Yibin,Yin Gang,Wang Yibaina,Shi Xiaolu,Cheng GongORCID

Abstract

AbstractViruses have developed various strategies to ensure their survival and transmission. One intriguing strategy involves manipulating the behavior of infected arthropod vectors and hosts. Through intricate interactions, viruses can modify vector behavior, aiding in crossing barriers and improving transmission to new hosts. This manipulation may include altering vector feeding preferences, thus promoting virus transmission to susceptible individuals. In addition, viruses employ diverse dissemination methods, including cell-to-cell and intercellular transmission via extracellular vesicles. These strategies allow viruses to establish themselves in favorable environments, optimize replication, and increase the likelihood of spreading to other individuals. Understanding these complex viral strategies offers valuable insights into their biology, transmission dynamics, and potential interventions for controlling infections. Unraveling interactions between viruses, hosts, and vectors enables the development of targeted approaches to effectively mitigate viral diseases and prevent transmission.

Funder

National Key Research and Development Plan of China

MOST | National Natural Science Foundation of China

Shenzhen San-Ming Project for Prevention and Research on Vector-borne Diseases

The Science and Technology Project of Southwest United Graduate School of Yunnan

The New Cornerstone Science Foundation through the New Cornerstone Investigator Program

The Xplorer Prize from Tencent Foundation

Publisher

Springer Science and Business Media LLC

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