High constitutive activity of native H3 receptors regulates histamine neurons in brain

Author:

Morisset Séverine,Rouleau Agnès,Ligneau Xavier,Gbahou Florence,Tardivel-Lacombe Joël,Stark Holger,Schunack Walter,Ganellin C. Robin,Arrang Jean-Michel

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference30 articles.

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2. Schütz, W. & Freissmuth, M. Reverse intrinsic activity of antagonists on G protein-coupled receptors. Trends Pharmacol. Sci. 13, 376–380 (1992).

3. Lefkowitz, R. J., Cotecchia, S., Samama, P. & Costa, T. Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins. Trends Pharmacol. Sci. 14, 303 –307 (1993).

4. Milligan, G., Bond, R. A. & Lee, M. Inverse agonism: pharmacological curiosity or potential therapeutic strategy? Trends Pharmacol. Sci. 16, 10–13 (1995).

5. Claeysen, S., Sebben, M., Becamel, C., Bockaert, J. & Dumuis, A. Novel brain-specific 5-HT4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain. Mol. Pharmacol. 55, 910– 920 (1999).

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