COX-2 and beyond: approaches to prostaglandin inhibition in human disease
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd1225.pdf
Reference147 articles.
1. Smith, W. L., Dewitt, D. L. & Garavito, R. M. Cyclooxygenases: structural, cellular, and molecular biology. Annu. Rev. Biochem. 69, 145–182 (2000). An excellent review of the structural biology of the COX isoforms and an overview of their biological relevance.
2. Malkowski, M. G., Ginell, S. L., Smith, W. L. & Garavito, R. M. The productive conformation of arachidonic acid bound to prostaglandin synthase. Science 289, 1933–1937 (2000).
3. Reid, G. et al. The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc. Natl Acad. Sci. USA 100, 9244–9249 (2003).
4. Schuster, V. L. Prostaglandin transport. Prostaglandins Other Lipid Mediat. 68–69, 633–647 (2002).
5. Vezza, R., Rokach, J., FitzGerald, G. A. Prostaglandin F2α receptor-dependent regulation of prostaglandin transport. Mol. Pharmacol. 59, 1506–1513 (2001).
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