Oral capecitabine vs intravenous 5-fluorouracil and leucovorin: integrated efficacy data and novel analyses from two large, randomised, phase III trials

Author:

Cutsem E Van,Hoff P M,Harper P,Bukowski R M,Cunningham D,Dufour P,Graeven U,Lokich J,Madajewicz S,Maroun J A,Marshall J L,Mitchell E P,Perez-Manga G,Rougier P,Schmiegel W,Schoelmerich J,Sobrero A,Schilsky R L

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Reference40 articles.

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2. Borner M, Dietrich D, Popescu R, Wernli M, Roth AD, Saletti P, Rauch DP, Herrmann R, Koberle D, Pestalozzi B, Honegger H, Castiglione-Gertsch M, Goldhirsch A (2003) A randomized phase II trial of capecitabine (CAP) and two different schedules of irinotecan (IRI) in first-line treatment of metastatic colorectal cancer (MCC). Proc Am Soc Clin Oncol 22: 266 (Abstract 1068)

3. Borner M, Schöffski P, de Wit R, Caponigro F, Comella G, Sulkes A, Greim G, Peters GJ, van der Born K, Wanders J, de Boer RF, Martin C, Fumoleau P (2002) Patient preference and pharmacokinetics of oral modulated UFT versus intravenous fluorouracil and leucovorin: a randomised crossover trial in advanced colorectal cancer. Eur J Cancer 38: 349–358

4. Cassidy J, Twelves C, Van Cutsem E, Hoff P, Bajetta E, Boyer M, Bugat R, Burger U, Garin A, Graeven U, McKendric J, Maroun J, Marshall J, Osterwalder B, Perez-Manga G, Rosso R, Rougier P, Schilsky RL, Capecitabine Colorectal Cancer Study Group (2002) First-line oral capecitabine therapy in metastatic colorectal cancer: a favorable safety profile compared with i.v. 5-fluorouracil (5-FU)/leucovorin. Ann Oncol 13: 566–575

5. Cunningham D, Pyrhönen S, James RD, Punt CJ, Hickish TF, Heikkila R, Johannesen TB, Starkhammar H, Topham CA, Awad L, Jacques C, Herait P (1998) Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer. Lancet 352: 1413–1418

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