ZD6474 – clinical experience to date

Author:

Heymach J V

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Reference37 articles.

1. Arao T, Fukumoto H, Takeda M, Tamura T, Saijo N, Nishio K (2004) Small in-frame deletion in the epidermal growth factor receptor as a target for ZD6474. Cancer Res 64: 9101–9104

2. Baker CH, Solorzano CC, Fidler IJ (2002) Blockade of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling for therapy of metastatic human pancreatic cancer. Cancer Res 62: 1996–2003

3. Briggs AD, Molofsky A, Wang J, Engelman P, Beaudry D, Prox D, Tracy S, Ryan AJ, Folkman J, Janne P, Johnson BE, Heymach JV (2005) Sensitivity of NSCLC cell lines bearing wild type and mutated EGFR to the VEGF/EGFR inhibitor ZD6474. Proc Am Assoc Cancer Res 46: abstract 5833

4. Bruns CJ, Solorzano CC, Harbison MT, Ozawa S, Tsan R, Fan D, Abbruzzese J, Traxler P, Buchdunger E, Radinsky R, Fidler IJ (2000) Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer Res 60: 2926–2935

5. Ciardiello F, Caputo R, Bianco R, Damiano V, Fontanini G, Cuccato S, De Placido S, Bianco AR, Tortora G (2001) Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor. Clin Cancer Res 7: 1459–1465

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