The pH partition theory predicts the accumulation and toxicity of doxorubicin in normal and low-pH-adapted cells

Author:

Gerweck L E,Kozin S V,Stocks S J

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Reference20 articles.

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2. Brophy, G. T. & Sladek, N. E. (1983). Influence of pH on the cytotoxic activity of chlorambucil. Biochem Pharma 32: 79–84.

3. Chu, G. L. & Dewey, W. C. (1988). The role of low intracellular or extracellular pH in sensitization to hyperthermia. Radiat Res 114: 154–167.

4. Dennis, M. F., Stratford, M. R. L., Wardman, P. & Watts, M. E. (1985). Cellular uptake of misonidazole and analogues with acidic or basic functions. Int J Radiat Biol 47: 629–643.

5. Durand, R. F. (1981). Flow cytometry studies of intracellular adriamycin in multicell spheroids in vitro. Cancer Res 41: 3495–3498.

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