Preclinical efficacy of the bioreductive alkylating agent RH1 against paediatric tumours

Author:

Hussein D,Holt S V,Brookes K E,Klymenko T,Adamski J K,Hogg A,Estlin E J,Ward T,Dive C,Makin G W J

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Reference35 articles.

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2. Begleiter A, Leith MK, Patel D, Hasinoff BB (2007) Role of NADPH cytochrome P450 reductase in activation of RH1. Cancer Chemother Pharmacol 60: 713–723

3. Berardini MD, Souhami RL, Lee CS, Gibson NW, Butler J, Hartley JA (1993) Two structurally related diaziridinylbenzoquinones preferentially cross-link DNA at different sites upon reduction with DT-diaphorase. Biochemistry 32: 3306–3312

4. Bligh HF, Bartoszek A, Robson CN, Hickson ID, Kasper CB, Beggs JD, Wolf CR (1990) Activation of mitomycin C by NADPH:cytochrome p-450 reductase. Cancer Res 50: 7789–7792

5. Brown JM, Giaccia AJ (1998) The unique physiology of solid tumours: opportunities and problems for cancer therapy. Cancer Res 58: 1408–1416

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