Identification of micromonolactam, a new polyene macrocyclic lactam from two marine Micromonospora strains using chemical and molecular methods: clarification of the biosynthetic pathway from a glutamate starter unit-Reference-Cited by-同舟云学术

Identification of micromonolactam, a new polyene macrocyclic lactam from two marine Micromonospora strains using chemical and molecular methods: clarification of the biosynthetic pathway from a glutamate starter unit

Published:2013-05-15 Issue:7 Volume:66 Page:431-441
ISSN:0021-8820
Container-title:The Journal of Antibiotics
language:en
Short-container-title:J Antibiot

Author:

Skellam Elizabeth Julia,Stewart Allison Kathleen,Strangman Wendy Karen,Wright Jeffrey Lawson Cameron

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmacology

Link

http://www.nature.com/articles/ja201334.pdf

Reference28 articles.

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2. Omura, S, Nakagawa, A, Shibata, K & Sano, H. The structure of hitachimycin, a novel macrocylic lactam involving β-phenylalanine. Tetrahedron Lett. 23, 4713–4716 (1982).

3. Kojiri, K, Nakajima, S, Suzuki, H, Kondo, H & Suda, H. A new macrocylic lactam antibiotic, BE-14106 I. taxonomy, isolation, biological activity, and structure elucidation. J. Antibiot. 45, 868–874 (1992).

4. Mitchell, S, Nicholson, B, Teisan, S, Lam, K & Potts, B. Aureoverticillactam, a novel 22-atom macrocylic lactam from the marine actinomycete Streptomyces aureoverticillatus. J. Nat. Prod. 67, 1400–1402 (2004).

5. Jorgensen, H et al. Insights into the evolution of macrolactam biosynthesis through cloning and comparative analysis of the biosynthetic gene cluster for a novel macrocyclic lactam, ML-449. Appl. Environ. Microbiol. 76, 283–293 (2010).

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