Elevated choline drives KLF5-dominated transcriptional reprogramming to facilitate liver cancer progression

Author:

Li Xinrong,Hu ZhixiangORCID,Shi Qili,Qiu Wenying,Liu Yizhe,Liu Yanfang,Huang ShenglinORCID,Liang LinhuiORCID,Chen ZhiaoORCID,He XianghuoORCID

Funder

National Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

Reference54 articles.

1. Inazu M. Choline transporter-like proteins CTLs/SLC44 family as a novel molecular target for cancer therapy. Biopharm Drug Dispos. 2014;35:431–49.

2. Aboagye EO, Bhujwalla ZM. Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells. Cancer Res. 1999;59:80–4.

3. Glunde K, Jie C, Bhujwalla ZM. Molecular causes of the aberrant choline phospholipid metabolism in breast cancer. Cancer Res. 2004;64:4270–6.

4. Katz-Brull R, Seger D, Rivenson-Segal D, Rushkin E, Degani H. Metabolic markers of breast cancer: enhanced choline metabolism and reduced choline-ether-phospholipid synthesis. Cancer Res. 2002;62:1966–70.

5. Gibellini F, Smith TK. The Kennedy pathway-De novo synthesis of phosphatidylethanolamine and phosphatidylcholine. IUBMB Life. 2010;62:414–28.

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