Structural basis of Smoothened regulation by its extracellular domains-Reference-Cited by-同舟云学术

Structural basis of Smoothened regulation by its extracellular domains

Published:2016-07 Issue:7613 Volume:535 Page:517-522
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Byrne Eamon F. X.,Sircar Ria,Miller Paul S.,Hedger George,Luchetti Giovanni,Nachtergaele Sigrid,Tully Mark D.,Mydock-McGrane Laurel,Covey Douglas F.,Rambo Robert P.,Sansom Mark S. P.,Newstead Simon,Rohatgi Rajat,Siebold Christian

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/nature18934.pdf

Reference87 articles.

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2. Taipale, J. et al. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature 406, 1005–1009 (2000).

3. Chen, J. K., Taipale, J., Cooper, M. K. & Beachy, P. A. Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev. 16, 2743–2748 (2002).

4. Chen, J. K., Taipale, J., Young, K. E., Maiti, T. & Beachy, P. A. Small molecule modulation of Smoothened activity. Proc. Natl Acad. Sci. USA 99, 14071–14076 (2002).

5. Frank-Kamenetsky, M. et al. Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. J. Biol. 1, 10 (2002).

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