Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1)-Reference-Cited by-同舟云学术

Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1)

Published:2016-03-31 Issue:1 Volume:6 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Schiaffino-Ortega Santiago,Baglioni Eleonora,Mariotto Elena,Bortolozzi Roberta,Serrán-Aguilera Lucía,Ríos-Marco Pablo,Carrasco-Jimenez M. Paz,Gallo Miguel A.,Hurtado-Guerrero Ramon,Marco Carmen,Basso Giuseppe,Viola Giampietro,Entrena Antonio,López-Cara Luisa Carlota

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/srep23793.pdf

Reference58 articles.

1. Adje, A. A. et al. Novel anticancer agents in clinical development. Cancer Biol. Ther. 2, S5–S15, (2003).

2. Neidle, S. et al. Chemical approaches to the discovery and development of cancer therapies. Nat. Rev. Cancer. 5, 285–296 (2005).

3. Kamb, S. et al. Why is cancer drug discovery so difficult? Nat. Rev. Drug Discov. 6, 115–120 (2007).

4. Brognard, J. & Hunter, T. Protein Kinase Signalling Networks in Cancer Curr Opin Genet Dev. 21, 4–11 (2011).

5. Reimand, J., Wagih, O. & Bader, G. D. The mutational landscape of phosphorylation signaling in cancer. Sci Rep. 3, 2651 (2013).

Cited by 23 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Directing novel ChoKα1 inhibitors using MamC-mediated biomimetic magnetic nanoparticles: a way to improve specificity and efficiency;Bioorganic Chemistry;2024-10

2. Choline kinase and miR-32-5p: A crucial interaction promoting apoptosis and delaying wound repair in cervical cancer cells;AIMS Biophysics;2024

3. Digital Cascade Assays for ADP- or ATP-Producing Enzymes Using a Femtoliter Reactor Array Device;ACS Sensors;2023-08-17

4. Mapping of exogenous choline uptake and metabolism in rat glioblastoma using deuterium metabolic imaging (DMI);Frontiers in Cellular Neuroscience;2023-04-28

5. New bioisosteric sulphur-containing choline kinase inhibitors with a tracked mode of action;European Journal of Medicinal Chemistry;2023-01