Determinants of enhancer and promoter activities of regulatory elements
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics (clinical),Genetics,Molecular Biology
Link
http://www.nature.com/articles/s41576-019-0173-8.pdf
Reference161 articles.
1. Maurano, M. T. et al. Systematic localization of common disease-associated variation in regulatory DNA. Science 337, 1190–1195 (2012).
2. Roadmap Epigenomics Consortium et al. Integrative analysis of 111 reference human epigenomes. Nature 518, 317–330 (2015).
3. Andersson, R. et al. An atlas of active enhancers across human cell types and tissues. Nature 507, 455–461 (2014). This is the largest study to date defining active enhancers from divergent TSSs of eRNAs. It demonstrates exosome-mediated decay of eRNAs and describes transcribed enhancers as being better validated in in vitro reporter assays than enhancers predicted from histone modifications.
4. Chatterjee, S. & Ahituv, N. Gene regulatory elements, major drivers of human disease. Annu. Rev. Genomics Hum. Genet. 18, 45–63 (2017).
5. Bradner, J. E., Hnisz, D. & Young, R. A. Transcriptional addiction in cancer. Cell 168, 629–643 (2017).
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