Generating specificity in genome regulation through transcription factor sensitivity to chromatin
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics (clinical),Genetics,Molecular Biology
Link
https://www.nature.com/articles/s41576-022-00512-6.pdf
Reference199 articles.
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2. Hansen, L., Mariño-Ramírez, L. & Landsman, D. Differences in local genomic context of bound and unbound motifs. Gene 506, 125–134 (2012).
3. Slattery, M. et al. Absence of a simple code: how transcription factors read the genome. Trends Biochem. Sci. 39, 381–399 (2014).
4. Wunderlich, Z. & Mirny, L. A. Different gene regulation strategies revealed by analysis of binding motifs. Trends Genet. 25, 434–440 (2009). This work comparing bacterial and eukaryotic TF motifs reveals that they use different strategies to achieve specificity in their respective genomes. Whereas bacterial motifs have sufficient information content for TFs to bind specific sites, eukaryotic motifs require clustering of motifs to achieve the same level of specificity.
5. Adams, C. C. & Workman, J. L. Binding of disparate transcriptional activators to nucleosomal DNA is inherently cooperative. Mol. Cell. Biol. 15, 1405–1421 (1995).
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