Associations between different dimensions of prenatal distress, neonatal hippocampal connectivity, and infant memory

Abstract

AbstractPrenatal maternal distress—an umbrella concept encompassing multiple negative psychological states including stress, anxiety, and depression—is a substantial prenatal exposure. Consistent across preclinical and human studies, the hippocampus displays alterations due to prenatal distress. Nevertheless, most prenatal distress studies do not focus on multiple dimensions of, have not examined hippocampal functional connectivity in association with, and do not consider observer-based functional outcomes related to distress. We investigated the effects of different dimensions of prenatal distress in pregnant adolescents, a population at high risk for distress, in association with neonatal hippocampal connectivity and infant memory. In pregnant adolescents (n = 42), we collected four measures of distress (perceived stress, depression, pregnancy-specific distress, and 24-h ambulatory salivary cortisol) during the 2nd and 3rd trimesters. Resting-state imaging data were acquired in their infants at 40–44 weeks post-menstrual age. Functional connectivity was measured from hippocampal seeds. Memory abilities were obtained at 4 months using the mobile conjugate reinforcement task. Shared across different dimensions of maternal distress, increased 3rd trimester maternal distress associated with weaker hippocampal–cingulate cortex connectivity and stronger hippocampal–temporal lobe connectivity. Perceived stress inversely correlated while hippocampal–cingulate cortex connectivity positively correlated with infant memory. Increased cortisol—collected during the 2nd, but not the 3rd, trimester—associated with weaker hippocampal–cingulate cortex connectivity and stronger hippocampal–temporal lobe connectivity. Different dimensions of prenatal maternal distress likely contribute shared and unique effects to shaping infant brain and behavior.