mGluR5 PAMs rescue cortical and behavioural defects in a mouse model of CDKL5 deficiency disorder-Reference-Cited by-同舟云学术

mGluR5 PAMs rescue cortical and behavioural defects in a mouse model of CDKL5 deficiency disorder

Published:2022-08-09 Issue:6 Volume:48 Page:877-886
ISSN:0893-133X
Container-title:Neuropsychopharmacology
language:en
Short-container-title:Neuropsychopharmacol.

Author:

Gurgone Antonia,Pizzo Riccardo,Raspanti Alessandra,Chiantia Giuseppe,Devi Sunaina,Comai Debora,Morello Noemi,Pilotto Federica,Gnavi Sara,Lupori Leonardo,Mazziotti Raffaele,Sagona Giulia,Putignano Elena,Nocentini Alessio,Supuran Claudiu T.,Marcantoni Andrea^ORCID,Pizzorusso Tommaso,Giustetto Maurizio^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Psychiatry and Mental health,Pharmacology

Link

https://www.nature.com/articles/s41386-022-01412-3.pdf

Reference60 articles.

1. Rusconi L, Salvatoni L, Giudici L, Bertani I, Kilstrup-Nielsen C, Broccoli V, et al. CDKL5 expression is modulated during neuronal development and its subcellular distribution is tightly regulated by the C-terminal tail. J Biol Chem. 2008;283:30101–11.

2. Baltussen LL, Negraes PD, Silvestre M, Claxton S, Moeskops M, Christodoulou E, et al. Chemical genetic identification of CDKL5 substrates reveals its role in neuronal microtubule dynamics. EMBO J. 2018;37:e99763.

3. Muñoz IM, Morgan ME, Peltier J, Weiland F, Gregorczyk M, Cm Brown F, et al. Phosphoproteomic screening identifies physiological substrates of the CDKL5 kinase. EMBO J. 2018;37:e99559.

4. Nawaz MS, Giarda E, Bedogni F, La Montanara P, Ricciardi S, Ciceri D, et al. CDKL5 and Shootin1 interact and concur in regulating neuronal polarization. PLoS One. 2016;11:e0148634.

5. Trazzi S, De Franceschi M, Fuchs C, Bastianini S, Viggiano R, Lupori L, et al. CDKL5 protein substitution therapy rescues neurological phenotypes of a mouse model of CDKL5 disorder. Hum Mol Genet. 2018;27:1572–92.

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. CDKL5’s role in microtubule-based transport and cognitive function;2024-08-29

2. Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability;Nature Communications;2023-12-11

3. Missense variants in RPH3A cause defects in excitatory synaptic function and are associated with a clinically variable neurodevelopmental disorder;Genetics in Medicine;2023-11

4. Stabilizing Immature Dendritic Spines in the Auditory Cortex: A Key Mechanism for mTORC1-Mediated Enhancement of Long-Term Fear Memories;The Journal of Neuroscience;2023-10-19

5. Metabotropic glutamate receptors (mGluRs) in epileptogenesis: an update on abnormal mGluRs signaling and its therapeutic implications;Neural Regeneration Research;2023-07-07