Revisiting the role of computational neuroimaging in the era of integrative neuroscience

Abstract

AbstractComputational models have become integral to human neuroimaging research, providing both mechanistic insights and predictive tools for human cognition and behavior. However, concerns persist regarding the ecological validity of lab-based neuroimaging studies and whether their spatiotemporal resolution is not sufficient for capturing neural dynamics. This review aims to re-examine the utility of computational neuroimaging, particularly in light of the growing prominence of alternative neuroscientific methods and the growing emphasis on more naturalistic behaviors and paradigms. Specifically, we will explore how computational modeling can both enhance the analysis of high-dimensional imaging datasets and, conversely, how neuroimaging, in conjunction with other data modalities, can inform computational models through the lens of neurobiological plausibility. Collectively, this evidence suggests that neuroimaging remains critical for human neuroscience research, and when enhanced by computational models, imaging can serve an important role in bridging levels of analysis and understanding. We conclude by proposing key directions for future research, emphasizing the development of standardized paradigms and the integrative use of computational modeling across neuroimaging techniques.